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Title: The clinical utility of testicular cancer risk loci.
Authors: Kratz CP,  Bratslavsky G,  Shi J
Journal: Genome Med
Date: 2011
Branches: BB, CGB
PubMed ID: 21255381
PMC ID: PMC3092086
Abstract: Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care.