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Title: N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.
Authors: Huang W,  Zheng W,  Urban DJ,  Inglese J,  Sidransky E,  Austin CP,  Thomas CJ
Journal: Bioorg Med Chem Lett
Date: 2007 Nov 1
Branches: OEEB
PubMed ID: 17827006
PMC ID: PMC2083578
Abstract: A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.