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Title: Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer.
Authors: Kim DH,  Smith-Warner SA,  Spiegelman D,  Yaun SS,  Colditz GA,  Freudenheim JL,  Giovannucci E,  Goldbohm RA,  Graham S,  Harnack L,  Jacobs EJ,  Leitzmann M,  Mannisto S,  Miller AB,  Potter JD,  Rohan TE,  Schatzkin A,  Speizer FE,  Stevens VL,  Stolzenberg-Solomon R,  Terry P,  Toniolo P,  Weijenberg MP,  Willett WC,  Wolk A,  Zeleniuch-Jacquotte A,  Hunter DJ
Journal: Cancer Causes Control
Date: 2010 Nov
Branches: NEB
PubMed ID: 20820900
PMC ID: PMC3082430
Abstract: OBJECTIVE: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. METHODS: Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. RESULTS: Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing ≥ 560 mcg/days vs. <240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 μg/day increase in total folate intake. CONCLUSION: These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.