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Title: Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density.
Authors: Hudson AG,  Reeves KW,  Modugno F,  Wilson JW,  Evans RW,  Vogel VG,  Gierach GL,  Simpson J,  Weissfeld JL
Journal: Nutr Cancer
Date: 2013
Branches: HREB
PubMed ID: 23530640
PMC ID: PMC3657737
Abstract: Diets low in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and high in omega-3 (n-3) PUFAs may protect against breast cancer development. Associations of PUFA intake with mammographic density, an intermediate marker of breast cancer risk, have been inconsistent; however, prior studies have relied on self-reported dietary PUFA intake. We examined the association between circulating erythrocyte n-6 and n-3 PUFAs with mammographic density in 248 postmenopausal women who were not taking exogenous hormones. PUFAs in erythrocytes were measured by gas-liquid chromatography, and mammographic density was assessed quantitatively by planimetry. Spearman's correlation coefficients and generalized linear models were used to evaluate the relationships between PUFA measures and mammographic density. None of the erythrocyte n-6 or n-3 PUFA measures were associated with percent density or dense breast area.