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||PHYSICAL ACTIVITY AND ENDOMETRIAL CANCER RISK IN THE NIH-AARP DIET AND HEALTH STUDY in: Abstracts of the 41st Annual Meeting of the Society for Epidemiologic Research
||Gierach G, Chang S, Brinton L, Lacey J, Hollenbeck A, Schatzkin A, Leitzmann M
||Am J Epidemiol
||2008 Jun 1
||EBP, HREB, NEB
||In line with recognition of a strong hormonal etiology, both obesity andphysical activity have been postulated to affect endometrial cancer risk.While obesity has been consistently related to risk, studies have derivedinconsistent results for physical activity. We examined relationships ofactivity patterns with endometrial cancer risk in the NIH-AARP Study cohort,which included 109,621 female members with no history of cancer,ages 50-71, who completed in 1995-1996 a mailed questionnaire capturingdaily routine and vigorous physical activity. Of these, 70,351 completeda second questionnaire with additional activity measures (1996-1997).State cancer registry linkage identified 1,052 primary endometrial cancersthrough December 2003. In multivariate proportional hazards models (includingbody mass index, BMI), increasing frequency of vigorous activity(any period of 20 minutes of activity causing increased breathing, heartrate or sweating) was associated with reduced endometrial cancer risk ina dose-response manner (p for trend = 0.02) (RR for 5 times/week vs.never/rarely = 0.77, 95% CI: 0.63, 0.95). The association with vigorousactivity was restricted to overweight and obese women, with no relationseen among thin women (BMI <25) (p for interaction = 0.12). We observedno associations with risk for light/moderate, routine or occupational physicalactivities. However, risk did increase with number of hours of dailysitting (p for trend = 0.03). The potential effects on risk of vigorous activities,as well as a possible interaction with BMI, may suggest directions forfuture research aimed at clarifying underlying mechanisms, including thoserelating to hormonal alterations.