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Title: Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
Authors: Conde L,  Halperin E,  Akers NK,  Brown KM,  Smedby KE,  Rothman N,  Nieters A,  Slager SL,  Brooks-Wilson A,  Agana L,  Riby J,  Liu J,  Adami HO,  Darabi H,  Hjalgrim H,  Low HQ,  Humphreys K,  Melbye M,  Chang ET,  Glimelius B,  Cozen W,  Davis S,  Hartge P,  Morton LM,  Schenk M,  Wang SS,  Armstrong B,  Kricker A,  Milliken S,  Purdue MP,  Vajdic CM,  Boyle P,  Lan Q,  Zahm SH,  Zhang Y,  Zheng T,  Becker N,  Benavente Y,  Boffetta P,  Brennan P,  Butterbach K,  Cocco P,  Foretova L,  Maynadié M,  de Sanjosé S,  Staines A,  Spinelli JJ,  Achenbach SJ,  Call TG,  Camp NJ,  Glenn M,  Caporaso NE,  Cerhan JR,  Cunningham JM,  Goldin LR,  Hanson CA,  Kay NE,  Lanasa MC,  Leis JF,  Marti GE,  Rabe KG,  Rassenti LZ,  Spector LG,  Strom SS,  Vachon CM,  Weinberg JB,  Holly EA,  Chanock S,  Smith MT,  Bracci PM,  Skibola CF
Journal: Nat Genet
Date: 2010 Aug
PubMed ID: 20639881
PMC ID: PMC2913472
Abstract: To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).