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Title: [Detection and characterization of gastric carcinoma associated with epstein-barr herpes virus].
Authors: Gurtsevich VE,  Galetskii SA,  Nered SN,  Novikova EV,  Iakovleva LS,  Land CE,  Davydov MI,  Klimenkov AA,  Petrovichev NN,  Tokunaga M
Journal: Vestn Ross Akad Med Nauk
Date: 1999
Branches: REB
PubMed ID: 10222834
PMC ID: not available
Abstract: The present investigation was carried out to estimate the incidence of Epstein-Barr virus (EBV)-associated cases among gastric carcinoma (GC) patients in Russia. Carcinoma specimens from 184 patients with GC treated at the Cancer Research Center were investigated by EBV encoded RNA-1 (EBER-1) in situ hybridization. Seventeen (9.24%) cases showed uniform EBER-1 expression restricted to the carcinoma cells. Hybridized signals were not detected in the non-neoplastic gastric epithelium. EBV involvement was significantly more frequent among males, especially in the tumors belonging to less differentiated types (moderately differentiated tubular adenocarcinomas and poorly differentiated solid adenocarcinomas) and located in the upper stomach (cardia and middle part). Most EBV-positive GCs were characterized by great lymphoid compartment involvement. The findings of the distribution of EBV-positive. GCs by sex, site, and histology are similar to those in Japan; however, the detection rate of EBV-positive cases in Russia is higher than that in Japan (6.7%) and lower than that in the USA (16%).