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||Serum Concentrations of Organochlorines and Risk of Melanoma: Results of a Prospective Analysis
||Engel LS, Andersen A, Barr DB, Cantor KP, Chou J, Hayes RB, Lan Q, Langseth H, Needham LL, Wacholder S, Blair A, Rothman N
||BB, OEEB, CGB, EBP, GEB
||Objective: To prospectively evaluate relationships of organochlorine pesticides and polychlorinated biphenyls (PCBs) with breast cancer, we conducted a case-control study nested in a cohort using the Columbia, Missouri Breast Cancer Serum Bank. Methods: Women donated blood in 197787, and during up to 9.5 years follow-up, 105 donors who met the inclusion criteria for the current study were diagnosed with breast cancer. For each case, two controls matched on age and date of blood collection were selected. Five DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] analogs, 13 other organochlorine pesticides, and 27 PCBs were measured in serum. Results: Women in the upper three quartiles of hexachlorobenzene were at twice the risk of breast cancer compared to those in the lowest quartile. However, there was no evidence for a dose-response relationship, and the association was limited to women whose blood was collected close to the time of diagnosis. Women with higher serum levels of other organochlorine pesticides and PCBs showed no increased risk of breast cancer overall, although positive associations were suggested for PCB-118 and PCB-138 when blood was collected close to the time of diagnosis. Conclusions: Results of this study do not support a role for organochlorine pesticides and PCBs in breast cancer etiology.