Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Comparison of two enzyme-linked immunosorbent assay tests for diagnosis of Helicobacter pylori infection in China.
Authors: Groves FD,  Zhang L,  Li JY,  You WC,  Chang YS,  Zhao L,  Liu WD,  Rabkin CS,  Perez-Perez GI,  Blaser MJ,  Gail MH
Journal: Cancer Epidemiol Biomarkers Prev
Date: 1997 Jul
Branches: BB, IIB, REB
PubMed ID: 9232345
PMC ID: not available
Abstract: An ELISA based on a pool of United States strains of Helicobacter pylori was compared with a newly developed ELISA based on a pool of Chinese strains. Both assays were tested using sera from 132 Chinese study subjects with biopsy-proven H. pylori infection. Using cutpoints designed to yield equal specificities of 94.9% in an uninfected control population, the sensitivity of the Chinese assay was 100.0%, compared to 97.7% for the United States assay (P = 0.25 by McNemar test). These results suggest that a H. pylori assay based on pooled antigens from United States strains will perform as well in the rural Chinese population as one based on antigens from Chinese strains.