Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Exome-wide association study of endometrial cancer in a multiethnic population.
Authors: Chen MM,  Crous-Bou M,  Setiawan VW,  Prescott J,  Olson SH,  Wentzensen N,  Black A,  Brinton L,  Chen C,  Chen C,  Cook LS,  Doherty J,  Friedenreich CM,  Hankinson SE,  Hartge P,  Henderson BE,  Hunter DJ,  Le Marchand L,  Liang X,  Lissowska J,  Lu L,  Orlow I,  Petruzella S,  Polidoro S,  Pooler L,  Rebbeck TR,  Risch H,  Sacerdote C,  Schumacher F,  Sheng X,  Shu XO,  Weiss NS,  Xia L,  Van Den Berg D,  Yang HP,  Yu H,  Chanock S,  Haiman C,  Kraft P,  De Vivo I
Journal: PLoS One
Date: 2014
Branches: EBP, MEB, LTG, OD, OEEB
PubMed ID: 24810602
PMC ID: PMC4014590
Abstract: Endometrial cancer (EC) contributes substantially to total burden of cancer morbidity and mortality in the United States. Family history is a known risk factor for EC, thus genetic factors may play a role in EC pathogenesis. Three previous genome-wide association studies (GWAS) have found only one locus associated with EC, suggesting that common variants with large effects may not contribute greatly to EC risk. Alternatively, we hypothesize that rare variants may contribute to EC risk. We conducted an exome-wide association study (EXWAS) of EC using the Infinium HumanExome BeadChip in order to identify rare variants associated with EC risk. We successfully genotyped 177,139 variants in a multiethnic population of 1,055 cases and 1,778 controls from four studies that were part of the Epidemiology of Endometrial Cancer Consortium (E2C2). No variants reached global significance in the study, suggesting that more power is needed to detect modest associations between rare genetic variants and risk of EC.