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Title: A genome-wide association study of breast cancer in women of African ancestry.
Authors: Chen F,  Chen GK,  Stram DO,  Millikan RC,  Ambrosone CB,  John EM,  Bernstein L,  Zheng W,  Palmer JR,  Hu JJ,  Rebbeck TR,  Ziegler RG,  Nyante S,  Bandera EV,  Ingles SA,  Press MF,  Ruiz-Narvaez EA,  Deming SL,  Rodriguez-Gil JL,  Demichele A,  Chanock SJ,  Blot W,  Signorello L,  Cai Q,  Li G,  Long J,  Huo D,  Zheng Y,  Cox NJ,  Olopade OI,  Ogundiran TO,  Adebamowo C,  Nathanson KL,  Domchek SM,  Simon MS,  Hennis A,  Nemesure B,  Wu SY,  Leske MC,  Ambs S,  Hutter CM,  Young A,  Kooperberg C,  Peters U,  Rhie SK,  Wan P,  Sheng X,  Pooler LC,  Van Den Berg DJ,  Le Marchand L,  Kolonel LN,  Henderson BE,  Haiman CA
Journal: Hum Genet
Date: 2013 Jan
Branches: CGR, EBP, MEB, LTG
PubMed ID: 22923054
PMC ID: PMC3749077
Abstract: Genome-wide association studies (GWAS) in diverse populations are needed to reveal variants that are more common and/or limited to defined populations. We conducted a GWAS of breast cancer in women of African ancestry, with genotyping of >1,000,000 SNPs in 3,153 African American cases and 2,831 controls, and replication testing of the top 66 associations in an additional 3,607 breast cancer cases and 11,330 controls of African ancestry. Two of the 66 SNPs replicated (p < 0.05) in stage 2, which reached statistical significance levels of 10(-6) and 10(-5) in the stage 1 and 2 combined analysis (rs4322600 at chromosome 14q31: OR = 1.18, p = 4.3 10(-6); rs10510333 at chromosome 3p26: OR = 1.15, p = 1.5 10(-5)). These suggestive risk loci have not been identified in previous GWAS in other populations and will need to be examined in additional samples. Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample.