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Title: GWAS meta-analysis of 16,852 women identifies new susceptibility locus for endometrial cancer.
Authors: Chen MM,  O'Mara TA,  Thompson DJ,  Painter JN,  Australian National Endometrial Cancer Study Group (ANECS),  Attia J,  Black A,  Brinton L,  Chanock S,  Chen C,  Cheng TH,  Cook LS,  Crous-Bou M,  Doherty J,  Friedenreich CM,  Garcia-Closas M,  Gaudet MM,  Gorman M,  Haiman C,  Hankinson SE,  Hartge P,  Henderson BE,  Hodgson S,  Holliday EG,  Horn-Ross PL,  Hunter DJ,  Le Marchand L,  Liang X,  Lissowska J,  Long J,  Lu L,  Magliocco AM,  Martin L,  McEvoy M,  National Study of Endometrial Cancer Genetics Group (NSECG),  Olson SH,  Orlow I,  Pooler L,  Prescott J,  Rastogi R,  Rebbeck TR,  Risch H,  Sacerdote C,  Schumacher F,  Setiawan VW,  Scott RJ,  Sheng X,  Shu XO,  Turman C,  Van Den Berg D,  Wang Z,  Weiss NS,  Wentzensen N,  Xia L,  Xiang YB,  Yang HP,  Yu H,  Zhang W,  Pharoah PD,  Dunning AM,  Tomlinson I,  Easton DF,  Kraft P,  Spurdle AB,  De Vivo I
Journal: Hum Mol Genet
Date: 2016 Mar 23
Branches: CGR, EBP, LGS, MEB, OD, OEEB
PubMed ID: 27008869
PMC ID: not available
Abstract: Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four GWAS (4,907 cases and 11,945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10(-8)) at 6p22.3 (rs1740828; P = 2.29 × 10(-8), OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.