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Title: Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study.
Authors: Chang CM,  Schroeder JC,  Huang WY,  Dunphy CH,  Baric RS,  Olshan AF,  Dorsey KC,  Dent GA,  Cerhan JR,  Lynch CF,  Rothman N,  Cantor KP,  Blair A
Journal: Leuk Res
Date: 2010 Feb
Branches: IIB, OEEB
PubMed ID: 19505720
PMC ID: PMC2815151
Abstract: We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.