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Title: Rapid Appearance of Rhabdomyosarcoma After Radiation and Chemotherapy for Retinoblastoma: A Clinicopathologic Correlation
Authors: Cebulla, CM,  Kleinerman RA,  Alegret A,  Kulak A,  Dubovy SR,  Hess DJ,  Murray TG
Journal: Retinal Cases & Brief Reports
Date: 2009
Branches: REB
PubMed ID:
PMC ID: not available
Abstract: Purpose: To report a clinicopathologic correlation of rhabdomyosarcoma appearing rapidly after external beam radiotherapy (EBRT) and systemic chemotherapy for bilateral retinoblastoma (RB) and compare this case with previously reported secondary rhabdomyosarcomas in RB survivors. Methods: We studied the case of a patient with bilateral RB who developed a rhabdomyosarcoma in the field of radiation after treatment with systemic chemotherapy and EBRT. We compared the timecourse of onset of rhabdomyosarcoma in this case to data from the largest two series of radiation-related rhabdomyosarcomas in RB patients. We correlated the pathology of the rhabdomyosarcoma with the clinical findings.