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||Detecting gene-environment interactions using a case-control design.
||Goldstein AM, Falk RT, Korczak JF, Lubin JH
||BB, MEB, GEB
||We assessed the sample size required for detecting gene-environment (G x E) interactions in a case-control study of complex diseases. The results suggest that large numbers of cases and controls will be required to detect G x E interaction for some odds ratio and exposure frequency combinations. These and other results suggest that alternative study designs may be needed to detect G x E interaction particularly with rare genes or uncommon environmental exposures.