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Title: Polymorphisms in EGFR and IL28B are associated with spontaneous clearance in an HCV-infected iranian population.
Authors: Carapito R,  Poustchi H,  Kwemou M,  Untrau M,  Sharifi AH,  Merat S,  Haj-Sheykholeslami A,  Jabbari H,  Esmaili S,  Michel S,  Toussaint J,  Le Gentil M,  Ansari-Moghaddam A,  Radosavljevic M,  Etemadi A,  Georgel P,  Malekzadeh R,  Bahram S
Journal: Genes Immun
Date: 2015 Dec
Branches: MEB
PubMed ID: 26378651
PMC ID: not available
Abstract: Although most hepatitis C virus (HCV)-infected individuals develop chronic infection, about 25% of them are able to clear the virus spontaneously without any therapeutic intervention. The aim of the present study was to identify genes associated with spontaneous HCV clearance in a population of Iranian patients. We genotyped 110 single-nucleotide polymorphisms (SNPs) in 59 selected--candidate--genes in a cohort of 107 HCV-infected participants who spontaneously cleared the infection and 176 participants whose infection persisted. Three out of the 110 SNPs were found to be associated with HCV outcome (P-values<0.03). rs11506105 in EGFR (epidermal growth factor receptor gene), and rs11881222 and rs12979860 in IL28B (interferon-λ3 gene). Multivariate logistic regression of the three markers showed that the A/A genotypes in both rs11506105 (EFGR) and rs11881222 (IL28B), and the C/C genotype in rs12979860 (IL28B) are associated with HCV clearance (recessive model: odds ratio (OR)=2.06, 95% confidence interval (95% CI)=1.09-3.88, P=0.025; OR=2.09, 95% CI=1.23-3.60, P=0.007; and OR=1.95, 95% CI=1.15-3.35, P=0.014 for rs11506105, rs12979860 and rs11881222, respectively). In conclusion, EGFR and IL28B SNPs are strong independent predictive markers of spontaneous viral clearance.