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Title: Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
Authors: Cerhan JR,  Berndt SI,  Vijai J,  Ghesquières H,  McKay J,  Wang SS,  Wang Z,  Yeager M,  Conde L,  de Bakker PI,  Nieters A,  Cox D,  Burdett L,  Monnereau A,  Flowers CR,  De Roos AJ,  Brooks-Wilson AR,  Lan Q,  Severi G,  Melbye M,  Gu J,  Jackson RD,  Kane E,  Teras LR,  Purdue MP,  Vajdic CM,  Spinelli JJ,  Giles GG,  Albanes D,  Kelly RS,  Zucca M,  Bertrand KA,  Zeleniuch-Jacquotte A,  Lawrence C,  Hutchinson A,  Zhi D,  Habermann TM,  Link BK,  Novak AJ,  Dogan A,  Asmann YW,  Liebow M,  Thompson CA,  Ansell SM,  Witzig TE,  Weiner GJ,  Veron AS,  Zelenika D,  Tilly H,  Haioun C,  Molina TJ,  Hjalgrim H,  Glimelius B,  Adami HO,  Bracci PM,  Riby J,  Smith MT,  Holly EA,  Cozen W,  Hartge P,  Morton LM,  Severson RK,  Tinker LF,  North KE,  Becker N,  Benavente Y,  Boffetta P,  Brennan P,  Foretova L,  Maynadie M,  Staines A,  Lightfoot T,  Crouch S,  Smith A,  Roman E,  Diver WR,  Offit K,  Zelenetz A,  Klein RJ,  Villano DJ,  Zheng T,  Zhang Y,  Holford TR,  Kricker A,  Turner J,  Southey MC,  Clavel J,  Virtamo J,  Weinstein S,  Riboli E,  Vineis P,  Kaaks R,  Trichopoulos D,  Vermeulen RC,  Boeing H,  Tjonneland A,  Angelucci E,  Di Lollo S,  Rais M,  Birmann BM,  Laden F,  Giovannucci E,  Kraft P,  Huang J,  Ma B,  Ye Y,  Chiu BC,  Sampson J,  Liang L,  Park JH,  Chung CC,  Weisenburger DD,  Chatterjee N,  Fraumeni JF Jr,  Slager SL,  Wu X,  de Sanjose S,  Smedby KE,  Salles G,  Skibola CF,  Rothman N,  Chanock SJ
Journal: Nat Genet
Date: 2014 Nov
Branches: BB, CGR, EBP, NEB, OD, OEEB, REB
PubMed ID: 25261932
PMC ID: PMC4213349
Abstract: Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.