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Title: Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins.
Authors: Cozen W,  Yu G,  Gail MH,  Ridaura VK,  Nathwani BN,  Hwang AE,  Hamilton AS,  Mack TM,  Gordon JI,  Goedert JJ
Journal: Br J Cancer
Date: 2013 Mar 19
Branches: BB, GEB, IIB
PubMed ID: 23443674
PMC ID: PMC3619077
Abstract: BACKGROUND: Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity. METHODS: We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within vs between twin pairs and by case-control status. RESULTS: The number of unique OTUs was more similar within twin pairs compared with randomly paired participants (P=0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338 vs 369, P=0.015); this difference was not significant (169 vs 183, P=0.10) when restricted to abundant OTUs. CONCLUSION: In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment.