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Title: Association Between Circulating Levels of Sex Steroid Hormones and Barrett's Esophagus in Men: a Case-Control Analysis.
Authors: Cook MB,  Wood SN,  Cash BD,  Young P,  Acosta RD,  Falk RT,  Pfeiffer RM,  Hu N,  Su H,  Wang L,  Wang C,  Gherman B,  Giffen C,  Dykes C,  Turcotte V,  Caron P,  Guillemette C,  Dawsey SM,  Abnet CC,  Hyland PL,  Taylor PR
Journal: Clin Gastroenterol Hepatol
Date: 2014 Aug 24
Branches: BB, GEB, HREB, NEB
PubMed ID: 25158929
PMC ID: not available
Abstract: BACKGROUND & AIMS: Esophageal adenocarcinoma is believed to result from the progression of gastroesophageal reflux disease to erosive esophagitis and re-epithelialization of the esophagus with a columnar cell population termed Barrett's esophagus (BE). Men develop BE and esophageal adenocarcinoma more frequently than women, and the ratio is increasing; approximately 7 men are diagnosed with malignancy for every woman, yet little is known about the mechanisms of this difference. We assessed whether sex steroid hormones were associated with BE in a male population. METHODS: We analyzed data from the Barrett's Esophagus Early Detection Case Control Study, based at the Walter Reed National Military Medical Center. Blood samples were collected from 173 men with BE and 213 men without BE (controls, based on endoscopic analysis); 13 sex steroid hormones were measured by mass spectrometry and sex hormone binding globulin was measured by enzyme-linked immunosorbent assay. We also calculated free estradiol, free testosterone, and free dihydrotestosterone (DHT). We used multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age, race, smoking status, alcohol consumption, body mass index (in kg/m(2)), heartburn, regurgitation, and gastroesophageal symptom score (excluding heartburn and regurgitation). RESULTS: Levels of free testosterone and free DHT were associated positively with BE risk; patients in the highest quartile for these hormones were most likely to have BE (free testosterone: OR, 5.36; 95% CI, 2.21-13.03; P = .0002; free DHT: OR, 4.25; 95% CI, 1.87-9.66; P = .001). Level of estrone sulfate was associated inversely with BE risk (P for trend = .02). No other hormone was associated with BE risk. Relationships were not modified by age or BMI. CONCLUSIONS: In an analysis of men, levels of free testosterone and free DHT were associated significantly with risk of BE.