Publications Search - Abstract View
| Title: |
Characterization of the HPV-specific memory B cell and systemic antibody responses in women receiving an unadjuvanted HPV16 L1 VLP vaccine. |
| Authors: |
Dauner JG, Pan Y, Hildesheim A, Harro C, Pinto LA |
| Journal: |
Vaccine |
| Date: |
2010 Jul 26 |
| Branches: |
LTG, IIB |
| PubMed ID: |
20591543 |
| PMC ID: |
PMC2913111 |
| Abstract: |
Human papillomavirus (HPV)-specific antibodies are proposed to be the correlate of protection afforded by HPV L1 virus-like particle (VLP) vaccines. Previous studies have characterized the systemic antibody response to immunization in terms of both the quantity and the ability to neutralize HPV. Here, we have adapted a generalized memory B cell ELISPOT to the HPV16 system and expanded the analysis of the systemic antibody response to include an avidity measurement of HPV L1 VLP-specific antibodies. We show the results of the memory B cell ELISPOT significantly correlated with IgG and neutralizing antibody titers, but not with the avidity measurement. This is the first comprehensive study to correlate a variety of humoral aspects potentially associated with protective immunity following vaccination with a HPV16 L1 VLP vaccine. |