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Title: Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
Authors: Bhatti P,  Doody MM,  Alexander BH,  Yuenger J,  Simon SL,  Weinstock RM,  Rosenstein M,  Stovall M,  Abend M,  Preston DL,  Pharoah P,  Struewing JP,  Sigurdson AJ
Journal: Cancer Epidemiol Biomarkers Prev
Date: 2008 Aug
Branches: CGB, CGR, REB
PubMed ID: 18708391
PMC ID: PMC2583248
Abstract: Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway.