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Title: The common D302H variant of CASP8 is associated with risk of glioma.
Authors: Bethke L,  Sullivan K,  Webb E,  Murray A,  Schoemaker M,  Auvinen A,  Kiuru A,  Salminen T,  Johansen C,  Christensen HC,  Muir K,  McKinney P,  Hepworth S,  Dimitropoulou P,  Lophatananon A,  Feychting M,  Lönn S,  Ahlbom A,  Malmer B,  Henriksson R,  Swerdlow A,  Houlston R
Journal: Cancer Epidemiol Biomarkers Prev
Date: 2008 Apr
Branches: REB
PubMed ID: 18398042
PMC ID: not available
Abstract: Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.