Publications Search - Abstract View
| Title: |
Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists. |
| Authors: |
Bhatti P, Doody MM, Alexander BH, Yuenger J, Simon SL, Weinstock RM, Rosenstein M, Stovall M, Abend M, Preston DL, Pharoah P, Struewing JP, Sigurdson AJ |
| Journal: |
Cancer Epidemiol Biomarkers Prev |
| Date: |
2008 Aug |
| Branches: |
REB, CGR, CGB |
| PubMed ID: |
18708391 |
| PMC ID: |
PMC2583248 |
| Abstract: |
Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway. |