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||Physical Activity and Risk of Male Breast Cancer.
||Arem H, Brinton LA, Moore SC, Gapstur SM, Habel LA, Johnson K, Kolonel LN, McCormack VA, Michels KB, Sesso HD, Ursin G, Van Den Eeden SK, Weiderpass E, Cook MB, Matthews CE
||Cancer Epidemiol Biomarkers Prev
||2015 Sep 24
||The association between leisure-time physical activity (LTPA) and male breast cancer risk (MBC) is unclear. In the MBC pooling project, with 449 cases and 13,855 matched controls, we used logistic regression with study stratification to generate adjusted odds ratios (OR) and 95% confidence intervals (CI) for LTPA tertiles and MBC risk. Compared with low LTPA, medium and high LTPA were not associated with MBC risk (OR=1.01, 95% CI 0.79-1.29; 0.90, 0.69-1.18, respectively). In joint-effects analyses, compared with the referent of high body mass index (BMI) (≥25 kg/m2)/low LTPA, neither medium nor high PA were associated with risk among high BMI men, but normal BMI men (<25 kg/m2) with low or medium LTPA were at a non-significant ~16% reduced risk and those with high LTPA were at a 27% reduced risk (OR=0.73, 95% CI 0.50-1.07). Physical activity alone may not confer protection against MBC risk.