Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Household solvent exposures and childhood acute lymphoblastic leukemia.
Authors: Freedman DM,  Stewart P,  Kleinerman RA,  Wacholder S,  Hatch EE,  Tarone RE,  Robison LL,  Linet MS
Journal: Am J Public Health
Date: 2001 Apr
Branches: REB, OEEB, BB
PubMed ID: 11291366
PMC ID: PMC1446651
Abstract: OBJECTIVES: This study explored the risk of childhood acute lymphoblastic leukemia (ALL) associated with participation by household members in hobbies or other home projects involving organic solvents. METHODS: Participants in this case-control study were 640 subjects with ALL and 640 matched controls. RESULTS: Childhood ALL was associated with frequent (> 4 times/month) exposure to model building (odds ratio [OR] = 1.9; 95% confidence interval [95% CI] = 0.7, 5.8) and artwork using solvents (OR = 4.1; 95% CI = 1.1, 15.1). We also found elevated risk (OR = 1.7; 95% CI = 1.1, 2.7) among children whose mothers lived in homes painted extensively (> 4 rooms) in the year before the children's birth. CONCLUSIONS: In this exploratory study, substantial participation by household members in some common household activities that involve organic solvents was associated with elevated risks of childhood ALL.