Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Bone marrow cell cycle markers in inherited bone marrow failure syndromes.
Authors: Al-Rahawan MM,  Alter BP,  Bryant BJ,  Elghetany MT
Journal: Leuk Res
Date: 2008 Dec
Branches: CGB
PubMed ID: 18606449
PMC ID: PMC2716700
Abstract: Patients with inherited bone marrow failure syndromes (IBMFS) are at increased risk of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), possibly related to cell cycle dysregulation. In a cross-sectional analysis of bone marrow from 77 IBMFS, 71 sporadic conditions (AML, MDS, acquired aplastic anemia) and 22 normal controls we found overexpression of p53 in IBMFS, AML, and MDS; of Ki-67 in IBMFS and AML; and of survivin in IBMFS compared with all other groups. The patterns of expression of cell cycle markers in IBMFS are thus distinct. Longitudinal studies will determine the diagnostic and prognostic significance of these findings.