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||Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China.
||Andreotti G, Hou L, Gao YT, Brinton LA, Rashid A, Chen J, Shen MC, Wang BS, Han TQ, Zhang BH, Sakoda LC, Fraumeni JF, Hsing AW
||Br J Cancer
||2010 Mar 30
||GEB, HREB, OD, OEEB
||BACKGROUND: Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear. METHODS: We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai. RESULTS: The effects of parity (odds ratios, OR(> or =3 vs 1 child)=2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR(per 1-year decrease)=1.2, 95% CI 0.99-1.6), and older age at menarche (OR(per 1-year increase)=1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant. CONCLUSION: Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.