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Title: A multiplex panel of plasma markers of immunity and inflammation in classical kaposi sarcoma.
Authors: Aka PV,  Kemp TJ,  Rabkin CS,  Shiels MS,  Polizzotto MN,  Lauria C,  Vitale F,  Pinto LA,  Goedert JJ
Journal: J Infect Dis
Date: 2015 Jan 15
Branches: IIB
PubMed ID: 25149762
PMC ID: PMC4334829
Abstract: Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we compared plasma from 15 human immunodeficiency virus (HIV)-negative classic KS cases to plasma from 29 matched controls, using a multiplex panel of immunity markers. Of 70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were strongly and significantly associated with KS, after adjustment for age and smoking status. These and previous observations are consistent with a tumor-promoting role for these cytokines, particularly CXCL10, but the small sample size and case-control design preclude firm conclusions on KS risk or pathogenesis. Larger, well-designed prospective studies are needed to better assess the association of these markers with KS.