Publications Search - Abstract View
||A multiplex panel of plasma markers of immunity and inflammation in classical kaposi sarcoma.
||Aka PV, Kemp TJ, Rabkin CS, Shiels MS, Polizzotto MN, Lauria C, Vitale F, Pinto LA, Goedert JJ
||J Infect Dis
||2015 Jan 15
||Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we compared plasma from 15 human immunodeficiency virus (HIV)-negative classic KS cases to plasma from 29 matched controls, using a multiplex panel of immunity markers. Of 70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were strongly and significantly associated with KS, after adjustment for age and smoking status. These and previous observations are consistent with a tumor-promoting role for these cytokines, particularly CXCL10, but the small sample size and case-control design preclude firm conclusions on KS risk or pathogenesis. Larger, well-designed prospective studies are needed to better assess the association of these markers with KS.