Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Haplotype analysis in population genetics and association studies.
Authors: Zhao H,  Pfeiffer R,  Gail MH
Journal: Pharmacogenomics
Date: 2003 Mar
Branches: BB
PubMed ID: 12605551
PMC ID: not available
Abstract: Several studies of haplotype structures in the human genome in various populations have been published recently. Such knowledge may provide valuable information on human evolutionary history and lead to the development of more efficient strategies to identify genetic variants that increase susceptibility to human diseases. In this review, we summarize the current understanding of haplotype structure, diversity, and distribution in the human genome, with a focus on statistical issues in using haplotypes for studies of population genetics and evolutionary history, as well as to identify genetic variants underlying complex human traits.