Skip to Content

Publications Search - Abstract View

Title: Hepatitis C virus infection, Linxian, China.
Authors: Zhang M,  Sun XD,  Mark SD,  Chen W,  Wong L,  Dawsey SM,  Qiao YL,  Fraumeni JF Jr,  Taylor PR,  O'Brien TR
Journal: Emerg Infect Dis
Date: 2005 Jan
Branches: IIB, BB, OD, NEB, GEB
PubMed ID: 15705317
PMC ID: PMC3294338
Abstract: Bloodborne viruses may have spread in rural China during the past 25 years, but population-based prevalence estimates are lacking. We examined the frequency of hepatitis C virus (HCV) and HIV type 1 (HIV-1) among residents of Linxian, a rural community in Henan Province. In 2000, blood was collected from participants (> or = 55 years of age) who had enrolled in a population-based nutritional intervention trial in 1985. We randomly selected 500 participants for HCV testing and 200 participants for HIV-1 testing. For HCV, 48 (9.6%) of 500 participants were positive by enzyme immunoassay and recombinant immunoblot assay (95% confidence interval, 7.0%-12.2%), and prevalence was lowest in the most geographically isolated participants. Among the HCV-infected participants, 42 had a specimen available from 1985, of which 16 (38.1%) were positive for HCV. For HIV-1, 0/200 participants were positive. We conclude that HCV is now a common infection among older adults in Linxian, China.